Pragney Deme

This study identifies bile acid signaling as a pathway linking early caregiving adversity to social behavior, showing that CDCA supplementation can rescue social deficits in a rat model.

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

PeakClimber accurately quantifies complex HPLC chromatograms using exponential Gaussian functions, outperforming existing tools in precision and applicability to biological samples.

The paper identifies a neurodegenerative microglia phenotype driven by the integrated stress response (ISR) and shows that inhibiting ISR ameliorates neurodegenerative pathologies in AD models.

The paper shows that indole lactate (ILA), reduced in MS, restores gut microbiome metabolic balance, promoting remyelination and reducing neuroinflammation.

This study shows that MCT1 in Schwann cells is essential for maintaining sensory nerve myelination during aging, leading to hypomyelination and impaired function.