Norman J. Haughey

This study identifies bile acid signaling as a pathway linking early caregiving adversity to social behavior, showing that CDCA supplementation can rescue social deficits in a rat model.

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

This study examines 15q11.2 deletion effects on neuronal development and function using iPSC-derived neurons, finding structural and functional impairments in network connectivity and maturation.

PeakClimber accurately quantifies complex HPLC chromatograms using exponential Gaussian functions, outperforming existing tools in precision and applicability to biological samples.

The paper identifies a neurodegenerative microglia phenotype driven by the integrated stress response (ISR) and shows that inhibiting ISR ameliorates neurodegenerative pathologies in AD models.

The paper shows that indole lactate (ILA), reduced in MS, restores gut microbiome metabolic balance, promoting remyelination and reducing neuroinflammation.

This study evaluates the impact of species and processing parameters on the recovery and content of brain tissue-derived extracellular vesicles using modified protocols.

This study shows that Cx43 hemichannels in astrocytes contribute to ALS progression and that blocking them can protect neurons and improve survival in ALS models.

This study investigates the effects of PCYT1A variants on lipid metabolism, chondrocyte differentiation, and lipid droplet formation using cellular models and lipidomics.

This paper develops a co-culture method for human iPSC-derived astrocytes and motor neurons in MEA systems, showing bidirectional maturation effects.

This study shows that MCT1 in Schwann cells is essential for maintaining sensory nerve myelination during aging, leading to hypomyelination and impaired function.

This study shows that inhibiting nSMase2 improves myelin quality by protecting oligodendrocytes during remyelination.