Age-dependent chemotherapy response and vitamin D impact in paired patient-derived normal and tumor colorectal organoids
Asunción Fernández‐Barral, Antonio Barbáchano, Silvia Rodriguez-Marrero, Luis del Peso, Alfonso Herreros‐Cabello, Nuria Rodríguez Salas, Isabel Prieto, Aurora Burgos, Miguel León Arellano, Damián García‐Olmo, Tomás Olleros, José Manuel González‐Sancho, María Jesús Larriba, Alberto Múñoz
The paper shows age-dependent differences in chemotherapy response and vitamin D's effect on drug sensitivity in colorectal organoids from early-onset and late-onset CRC patients.
bioRxiv · Dec 17, 2025 · PreprintCancer Biology