Luis del Peso

The paper generates a single-cell transcriptomic dataset of murine embryoid bodies under hypoxia and normoxia to study oxygen's impact on lineage specification and cellular heterogeneity during early development.

This study identifies VCAN as a novel transcriptional target of ERK5 and shows its essential role in ERK5-driven tumorigenesis in soft tissue sarcoma.

The paper improves TFEA.ChIP by integrating ENCODE regulatory maps, enhancing accuracy in identifying transcription factor enrichment from gene expression data.

The paper shows age-dependent differences in chemotherapy response and vitamin D's effect on drug sensitivity in colorectal organoids from early-onset and late-onset CRC patients.

This study shows intermittent hypoxia impairs brown adipose tissue function through molecular and morphological changes, preceding systemic metabolic dysfunction in mice.

The paper develops hypoxia classifiers using decision trees from a meta-analysis of RNA-seq data, achieving high accuracy in identifying hypoxic samples across diverse datasets.

The paper performs a meta-analysis of hypoxia gene expression data to identify a universal gene signature and cell-type-specific effects.

This study uses metabolic labeling to quantify how hypoxia affects RNA levels through transcription and decay rates, finding that transcription is the main driver but degradation also contributes significantly.

TFEA.ChIP identifies transcription factor enrichment in gene lists using ChIP-Seq data, achieving high accuracy in identifying relevant TFs.

The paper identifies SIN3A's role in hypoxia-induced transcriptional changes, showing it represses 75% of hypoxia-repressed genes and inhibits 47% of hypoxia-induced genes.