Synaptic Toxicity of OGA Inhibitors and the Failure of Ceperognastat
Jonathan Meade, Haylee Mesa, Shahriar Alamgir, Isabell Bieniecka, Lei Liu, Qi Zhang
This study shows that OGA inhibitors impair synaptic plasticity and cause synaptotoxic effects in mouse hippocampal slices, suggesting potential risks for Alzheimer's disease therapies.
The Journal of Prevention of Alzheimer s Disease · Jan 1, 2026Peer-reviewedPharmacology & Toxicology