Jonathan Meade

This paper develops a DAG-mimetic fluorescent probe, DONDI-5, to visualize diacylglycerol dynamics at lipid droplets and shows DAGs can be stored there without converting to triacylglycerols.

This study shows that OGA inhibitors impair synaptic plasticity and cause synaptotoxic effects in mouse hippocampal slices, suggesting potential risks for Alzheimer's disease therapies.

The paper develops modular fluorescent cholesterol analogs to study subcellular cholesterol trafficking, showing that head group modifications affect internalization efficiency and subcellular distribution.