Karen M. Cichowski

This study identifies BRD2 as a co-targetable vulnerability with PI3K/AKT inhibitors in breast cancer, showing that BRD2 phosphorylation is required for chromatin binding and that targeting BRD2 enhances drug efficacy.

This paper develops a digital twin model to optimize epigenetic therapies in triple-negative breast cancer by simulating treatment responses and identifying effective drug combinations.

This study identifies a synergistic effect between AKT inhibitors and pitavastatin in killing triple-negative breast cancer cells by targeting cholesterol trafficking.