Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of Rspo1 in mouse sex reversal
Nainoa Richardson, Isabelle Gillot, Elodie P. Gregoire, Sameh A. Youssef, Dirk G. de Rooij, Alain de Bruin, Marie‐Cécile De Cian, Marie‐Christine Chaboissier
The paper shows that Sox8 and Sox9 redundantly compensate for Rspo1 loss in female-to-male sex reversal in mice, preventing ovarian-to-testicular reprogramming.
eLife · May 25, 2020Peer-reviewedDevelopmental Biology