Dirk G. de Rooij

This study identifies Y-chromosome gene functions in mouse spermatogenesis by generating Y-deletion models and analyzing gene effects on fertility.

The paper shows that the MEIOC-YTHDC2-RBM46 complex destabilizes mRNAs of transcriptional repressors in mouse spermatogenic cells, enhancing their competence to initiate meiosis in response to retinoic acid.

This study shows that Actl7b deficiency in mice causes spermatogenic arrest and cytoskeletal defects in spermatids due to mislocalization of LC8 dynein light chains.

This study shows CBX2 is required for spermatogonial differentiation and long-term maintenance of male germ cells through chromatin compaction and phase separation.

The paper shows that A-MYB activates TCFL5, which is essential for meiosis and spermiogenesis in placental mammals, and its loss causes sterility.

The paper identifies a missense variant in HSF2BP linked to POI, showing it impairs meiotic recombination by affecting its interaction with MIDAP and reducing recombinase activity.

This study shows DAZL regulates spermatogonial progenitor expansion and differentiation by enhancing translation of its target genes.

The paper shows that Sox8 and Sox9 redundantly compensate for Rspo1 loss in female-to-male sex reversal in mice, preventing ovarian-to-testicular reprogramming.

The paper shows GCNA interacts with Topoisomerase II to resolve DNA-protein crosslinks, maintaining genome stability in germline and early embryos.

This paper introduces a method to isolate high-purity populations of male germ cells from mice by synchronizing development, staging, and sorting, achieving ~90% purity at each developmental step.