Alain de Bruin

The paper develops an in vitro MASH model to study metabolite crosstalk between Kupffer cells and hepatocytes, identifying itaconate as a key mediator of liver disease progression.

This study shows that chromosomal instability (CIN) can both promote and suppress tumor formation depending on its level, with high CIN acting non-cell-autonomously to drive tumor relapse.

This study shows that SERF2 deletion changes amyloid fibril structure in Alzheimer's mouse models, suggesting SERF's role in modifying amyloid aggregation.

The paper shows that Sox8 and Sox9 redundantly compensate for Rspo1 loss in female-to-male sex reversal in mice, preventing ovarian-to-testicular reprogramming.