Sameh A. Youssef

Non-cell-autonomous mechanisms of tumor initiation and relapse by chromosomal instability

This study shows that chromosomal instability (CIN) can both promote and suppress tumor formation depending on its level, with high CIN acting non-cell-autonomously to drive tumor relapse.

SERF deletion modifies amyloid aggregation in a mouse model of Alzheimer's disease

This study shows that SERF2 deletion changes amyloid fibril structure in Alzheimer's mouse models, suggesting SERF's role in modifying amyloid aggregation.

Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of Rspo1 in mouse sex reversal

The paper shows that Sox8 and Sox9 redundantly compensate for Rspo1 loss in female-to-male sex reversal in mice, preventing ovarian-to-testicular reprogramming.