High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimers Disease
Kai Saito, Danielle S. Goulding, Georgia L. Nolt, Sophia H. Dimas, Lauren C. Moore, Isaiah O. Stevens, Sonya Anderson, James Andy Snipes, Shannon L. Macauley, Peter T. Nelson, Lance A. Johnson, Josh M. Morganti
This study uses spatial transcriptomics to show that proximity to amyloid plaques in AD models alters microglial metabolism, revealing conserved patterns in human tissue.
bioRxiv · May 16, 2025 · PreprintNeuroscience