Author

Kai Saito

University of Kentucky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 3 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 4 Organism:mouse· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Josh M. MorgantiiD· 4 shared Danielle S. Goulding· 2 shared Georgia L. NoltiD· 2 shared Lance A. JohnsoniD· 2 shared Shannon L. MacauleyiD· 2 shared Abigail Carter· 1 shared Akhil V. PallerlaiD· 1 shared Alexander G. RabchevskyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Josh M. MorgantiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like events

Akhil V. Pallerla, Chloe C. Lucido, Kai Saito, Georgia L. Nolt, José Miguel Arbonés-Mainar, Jessica L. Funnell, Diksha Satish, Lily M. Smith, Isaiah O. Stephens, Danielle S. Goulding, Steven M. MacLean, Samantha M Olmsted, Darcy Adreon, Gabriela Hernandez, Lesley R. Golden, , Lance A. Johnson

This study investigates how anti-amyloid immunotherapy affects APOE4 carriers, showing increased glial reactivity, perivascular immune activation, and ARIA-like events.

bioRxiv · Jun 29, 2026 · PreprintNeuroscience

Astrocytic response to traumatic brain injury to rescue neuronal mitochondrial dysfunction through mitochondrial transfer

Gopal V. Velmurugan, Hemendra J. Vekaria, Alexander G. Rabchevsky, Kai Saito, Josh M. Morganti, Samir P. Patel, W. Brad Hubbard, Patrick G. Sullivan

This study shows astrocytes transfer mitochondria to neurons after TBI to support mitochondrial function in neuronal soma, dendrites, and axons but not synapses, and demonstrates therapeutic potential of exogenous mitochondrial transfer via extracellular vesicles.

bioRxiv · Jan 23, 2026 · PreprintNeuroscience

Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers Apolipoprotein B Containing Lipoproteins in Mice

Robert Nathaniel Helsley, Mikala M. Zelows, Victoria P. Noffsinger, Garrett Anspach, Nikitha Dharanipragada, Anna E. Mead, Isidoro Cobo, Abigail Carter, Qinglin Wu, IRINA Y. SHALAUROVA, Kai Saito, Josh M. Morganti, Scott M. Gordon, Gregory A. Graf

This study shows that reducing CPT1a in the liver lowers apoB-containing lipoproteins and cholesterol in mice, with increased clearance of these lipoproteins linked to enhanced PPAR signaling.

Arteriosclerosis Thrombosis and Vascular Biology · Jun 12, 2025Peer-reviewedPhysiology

High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimers Disease

Kai Saito, Danielle S. Goulding, Georgia L. Nolt, Sophia H. Dimas, Lauren C. Moore, Isaiah O. Stevens, Sonya Anderson, James Andy Snipes, Shannon L. Macauley, Peter T. Nelson, Lance A. Johnson, Josh M. Morganti

This study uses spatial transcriptomics to show that proximity to amyloid plaques in AD models alters microglial metabolism, revealing conserved patterns in human tissue.

bioRxiv · May 16, 2025 · PreprintNeuroscience