Josh M. Morganti

Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like events

This study investigates how anti-amyloid immunotherapy affects APOE4 carriers, showing increased glial reactivity, perivascular immune activation, and ARIA-like events.

Astrocytic response to traumatic brain injury to rescue neuronal mitochondrial dysfunction through mitochondrial transfer

This study shows astrocytes transfer mitochondria to neurons after TBI to support mitochondrial function in neuronal soma, dendrites, and axons but not synapses, and demonstrates therapeutic potential of exogenous mitochondrial transfer via extracellular vesicles.

Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers Apolipoprotein B Containing Lipoproteins in Mice

This study shows that reducing CPT1a in the liver lowers apoB-containing lipoproteins and cholesterol in mice, with increased clearance of these lipoproteins linked to enhanced PPAR signaling.

APOE4 alters the lipid droplet proteome and modulates droplet dynamics

This study shows that APOE4 increases lipid droplet accumulation and alters their composition in microglia, resembling a pro-inflammatory state, and overlaps with AD-associated proteomes.

High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimers Disease

This study uses spatial transcriptomics to show that proximity to amyloid plaques in AD models alters microglial metabolism, revealing conserved patterns in human tissue.

APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

This study investigates how APOE4 affects microglial immunometabolism across age, amyloid pathology, and inflammation using multi-omics approaches.

ApoE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes

This study shows that ApoE4 alters astrocyte immunometabolic responses to inflammation by changing their transcriptional profiles and relying on cRel transcription factor activity.

APOE4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis

This study identifies APOE4-associated metabolic changes in brain and systemic metabolism, showing increased aerobic glycolysis and reduced oxidative metabolism in both mice and humans.

Validation and standardization of a new radial-arm water maze protocol using a murine model of mild closed head traumatic brain injury

This study validates and standardizes a radial-arm water maze protocol in mice to assess cognitive impairments after mild closed head traumatic brain injury.

Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice

This study investigates how aging affects astrocyte responses to traumatic brain injury in mice, finding age-related impairments in homeostatic functions and altered reactive astrogliosis.