Author

Danielle S. Goulding

University of Kentucky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:spatial transcriptomics· 4 Approach:statistical model· 4 Organism:human· 3 Organism:mouse· 3 Approach:experimental assay· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Josh M. MorgantiiD· 4 shared Lance A. JohnsoniD· 4 shared Shannon L. MacauleyiD· 3 shared Adeline E. WalshiD· 2 shared Amy A. Gorman· 2 shared Georgia L. NoltiD· 2 shared Holden C. WilliamsiD· 2 shared James L. Schwartz· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersNeuroscience

Josh M. MorgantiORCID

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Author profile →

4 papers

Recent·Most cited

Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like events

Akhil V. Pallerla, Chloe C. Lucido, Kai Saito, Georgia L. Nolt, José Miguel Arbonés-Mainar, Jessica L. Funnell, Diksha Satish, Lily M. Smith, Isaiah O. Stephens, Danielle S. Goulding, Steven M. MacLean, Samantha M Olmsted, Darcy Adreon, Gabriela Hernandez, Lesley R. Golden, , Lance A. Johnson

This study investigates how anti-amyloid immunotherapy affects APOE4 carriers, showing increased glial reactivity, perivascular immune activation, and ARIA-like events.

bioRxiv · Jun 29, 2026 · PreprintNeuroscience

High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimers Disease

Kai Saito, Danielle S. Goulding, Georgia L. Nolt, Sophia H. Dimas, Lauren C. Moore, Isaiah O. Stevens, Sonya Anderson, James Andy Snipes, Shannon L. Macauley, Peter T. Nelson, Lance A. Johnson, Josh M. Morganti

This study uses spatial transcriptomics to show that proximity to amyloid plaques in AD models alters microglial metabolism, revealing conserved patterns in human tissue.

bioRxiv · May 16, 2025 · PreprintNeuroscience

APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

Sangderk Lee, Nicholas A. Devanney, Lesley R. Golden, Cathryn T Smith, James L. Schwartz, Adeline E. Walsh, Harrison A. Clarke, Danielle S. Goulding, Elizabeth J. Allenger, Gabriella Morillo Segovia, Cassi M. Friday, Amy A. Gorman, Tara R. Hawkinson, Steven M. MacLean, Holden C. Williams, , Lance A. Johnson

This study investigates how APOE4 affects microglial immunometabolism across age, amyloid pathology, and inflammation using multi-omics approaches.

Cell Reports · Mar 1, 2023Peer-reviewedNeuroscience

ApoE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes

Sangderk Lee, Holden C. Williams, Amy A. Gorman, Nicholas A. Devanney, Douglas A. Harrison, Adeline E. Walsh, Danielle S. Goulding, Tony Tuck, James L. Schwartz, Diana J. Zajac, Shannon L. Macauley, Steven Estus, Julia TCW, Lance A. Johnson, Josh M. Morganti

This study shows that ApoE4 alters astrocyte immunometabolic responses to inflammation by changing their transcriptional profiles and relying on cRel transcription factor activity.

bioRxiv · Feb 6, 2023 · PreprintNeuroscience