Author

Isaiah Wilt

National Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:microscopy & imaging analysis· 1 Approach:statistical model· 1

Frequent Co-Authors

Abigail A. JolleyiD· 3 shared Alex A. ComptoniD· 3 shared Kazi RahmaniD· 2 shared Kin Kui LaiiD· 2 shared Mahesh AgarwaliD· 2 shared Bhabadeb ChowdhuryiD· 1 shared Guoli Shi· 1 shared Mary K. LewinskiiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

Abigail A. JolleyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

IFITM1 and IFITM3 cooperate to restrict virus entry in endolysosomes

Isaiah Wilt, Abigail A. Jolley, Kazi Rahman, Kin Kui Lai, Mahesh Agarwal, Guoli Shi, Þorkell Andrésson, Alex A. Compton

This study shows that IFITM1 and IFITM3 work together to block virus entry in endolysosomes, with IFITM3 promoting IFITM1 localization to these compartments.

Journal of Virology · Jun 9, 2026Peer-reviewedMicrobiology

Restriction of HIV-1 infectivity by interferon and IFITM3 is counteracted by Nef

Mahesh Agarwal, Kin Kui Lai, Isaiah Wilt, Saliha Majdoul, Abigail A. Jolley, Mary K. Lewinski, Alex A. Compton

This study shows that HIV-1 Nef counteracts the antiviral effects of IFITM3 in interferon-treated cells by reducing its cell surface levels and impairing its function.

Science Advances · Oct 1, 2025Peer-reviewedMicrobiology

SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion

Kazi Rahman, Isaiah Wilt, Abigail A. Jolley, Bhabadeb Chowdhury, Siddhartha A.K. Datta, Alex A. Compton

The paper identifies a SNARE-like motif in the CD225 domain of IFITM3 that modulates SNARE complex assembly and endosomal fusion, revealing a mechanism for its antiviral activity.

The EMBO Journal · Dec 9, 2024Peer-reviewedCell Biology