SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion
Kazi Rahman, Isaiah Wilt, Abigail A. Jolley, Bhabadeb Chowdhury, Siddhartha A.K. Datta, Alex A. Compton
The paper identifies a SNARE-like motif in the CD225 domain of IFITM3 that modulates SNARE complex assembly and endosomal fusion, revealing a mechanism for its antiviral activity.
The EMBO Journal · Dec 9, 2024Peer-reviewedCell Biology