Directed evolution of a thermostable family-A DNA polymerase into a reverse transcriptase for 2'-modified RNA
Eloi Vincent, Clement Lopez, Rémi Sieskind, Isciane Commenge, Rafael Navaza, Ahmed Haouz, Marc H. Delarue
This study evolves a DNA polymerase into a reverse transcriptase for modified RNA using directed evolution, revealing sequence-to-function relationships through integrated analysis.
bioRxiv · Oct 9, 2026 · PreprintSynthetic Biology