Rémi Sieskind

The paper presents cryo-EM structures of phage A-family DNA polymerases fused to a uracil-DNA glycosylase domain, revealing their role in reading dU bases and repairing abasic sites during replication.

This study evolves a DNA polymerase into a reverse transcriptase for modified RNA using directed evolution, revealing sequence-to-function relationships through integrated analysis.

This paper evolves a DNA polymerase to synthesize glycosylated xeno-nucleic acids with base and backbone modifications, enabling new chemical functionality in genetic polymers.

The paper demonstrates that synthetic cells with minimal metabolism can undergo Darwinian evolution by filtering functional genotypes and mapping mutations in a key enzyme.