Author

Rafael Navaza

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2

Frequent Co-Authors

Clement LopeziD· 2 shared Eloi VincentiD· 2 shared Marc H. DelarueiD· 2 shared Rémi SieskindiD· 2 shared Ahmed HaouziD· 1 shared Isciane Commenge· 1 shared John Charles ChaputiD· 1 shared Laurence A. MulardiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersSynthetic Biology

Clement LopezORCID

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2 papers

Recent·Most cited

Directed evolution of a thermostable family-A DNA polymerase into a reverse transcriptase for 2'-modified RNA

Eloi Vincent, Clement Lopez, Rémi Sieskind, Isciane Commenge, Rafael Navaza, Ahmed Haouz, Marc H. Delarue

This study evolves a DNA polymerase into a reverse transcriptase for modified RNA using directed evolution, revealing sequence-to-function relationships through integrated analysis.

bioRxiv · Oct 9, 2026 · PreprintSynthetic Biology

Polymerase Evolution Enables Access to Glycosylated Xeno-Nucleic Acids with Expanded Chemical Functionality

Eloi Vincent, Victoria A. Maola, Clement Lopez, Marc Borie-Guichot, Maria Dalla Pozza, Mohammad Hajjar, Rémi Sieskind, Soizick Lucas‐Staat, Rafael Navaza, Laurence A. Mulard, Marcel Hollenstein, John Charles Chaput, Marc H. Delarue

This paper evolves a DNA polymerase to synthesize glycosylated xeno-nucleic acids with base and backbone modifications, enabling new chemical functionality in genetic polymers.

bioRxiv · Jul 21, 2026 · PreprintSynthetic Biology