Author

Isha Malik

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Andrew E. CornishiD· 1 shared Chaucie Edwards· 1 shared Julia S. BrunneriD· 1 shared Kristelle J. CapistranoiD· 1 shared Lydia W.S. FinleyiD· 1 shared Mark H. GinsbergiD· 1 shared Megan S. LimiD· 1 shared Ming O. LiiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Andrew E. CornishORCID

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1 paper

Recent·Most cited

Onco-Circuit Addiction and Onco-Nutrient mTORC1 Signaling Vulnerability in a Model of Aggressive T Cell Malignancy

Xinxin Wang, Andrew E. Cornish, Mytrang Do, Julia S. Brunner, Ting-Wei Hsu, Zijian Xu, Isha Malik, Chaucie Edwards, Kristelle J. Capistrano, Xian Zhang, Mark H. Ginsberg, Lydia W.S. Finley, Megan S. Lim, Steven Michael Horwitz, Ming O. Li

The paper shows that mTORC1 signaling hypersensitivity to leucine drives an onco-circuit in T cell malignancy, and a low leucine diet is therapeutic without impairing T cell immunity.

bioRxiv · Apr 3, 2024 · PreprintCancer Biology