α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex
Tanzila Mukhtar, Clara Siebert, Yuejun Jessie Wang, Mark-Phillip Pebworth, Matthew L. White, Tianzhi Wu, Tao Huang, Guolong Zuo, Jayden M. Ross, Jennifer Baltazar, Varun Upadhyay, Merut Shankar, Li Zhou, Isabel Lombardi-Coronel, Ishaan Mandala, , Arnold R. Kriegstein
This study shows that α7 nicotinic acetylcholine receptors influence radial glia fate in human cortical development, with nicotine exposure altering neuronal differentiation and RG proliferation.
Nature Communications · Jul 1, 2025Peer-reviewedNeuroscience