Arnold R. Kriegstein

The paper identifies a novel ependymal cell type (E2) in the forebrain that senses cerebrospinal fluid signals via specialized cilia and Smoothened receptor.

The paper provides a high-resolution molecular and cellular analysis of Broca's area and motor cortex across developmental stages, identifying distinct cellular signatures and vulnerabilities to neurodevelopmental disorders.

This study develops a single-cell proteomics workflow to analyze the developing human brain, revealing transcriptome-proteome discordance and identifying molecular vulnerabilities in neurodevelopmental disorders.

This paper introduces vascularized cortical assembloids (vCAs) that model neurovascular co-development and show improved cellular specialization and connectivity compared to standard cortical organoids.

The paper identifies distinct progenitor populations in human ganglionic eminences, their gene regulatory networks, and lineage trajectories using single-nucleus transcriptomics and spatial transcriptomics.

This study identifies a mechanism by which skull bone marrow-derived HSPCs and CD4+ T cells promote immunotolerance in childhood brain tumours, showing that antibody therapy targeting CSF cytokines can disrupt this process and induce tumour regression.

This study uses single-cell analysis of dup15q syndrome to identify developmental and postnatal molecular changes in autism, revealing cell-type specific dysregulation and shared vulnerabilities with idiopathic ASD.

This study shows that α7 nicotinic acetylcholine receptors influence radial glia fate in human cortical development, with nicotine exposure altering neuronal differentiation and RG proliferation.

This study shows that the identity of MGE-derived cortical interneurons can be dynamically influenced by their environment, with human 3D models promoting Pvalb expression over Sst.

This study maps the molecular and cellular dynamics of the developing human neocortex using single-nucleus data, revealing gene regulatory networks and a cancer-related progenitor subtype.

The paper maps the spatial distribution of retinal ganglion cell types and identifies perivascular RGCs that show neuroprotection after optic nerve injury.

The paper investigates the substructure and maturation of lamina-associated domains (LADs) in postmitotic neurons across human brain development, revealing dynamic changes in T1 and T2 LADs.

This study shows that ADGRG1 in microglia helps protect against Alzheimer's disease by improving amyloid clearance and reducing pathology.

This study shows that spatial genome organization in human neurogenesis affects bivalent chromatin activity by relocating genes from the nuclear lamina to speckles, increasing transcription and resolving chromatin states.

Spatial tri-omic sequencing (DBiT ARP-seq and DBiT CTRP-seq) and CODEX imaging map chromatin, RNA, and protein dynamics across mammalian brain development and lysolecithin-induced neuroinflammation.

The paper uses single-cell genomics to reconstruct developmental trajectories of 170 neuronal subtypes in the human hypothalamus across development.

The paper constructs a single-cell transcriptomic atlas of human cortical development, identifying lineage and sex-specific gene expression programs linked to autism risk.

This study creates a cross-species proteomic map of synapse development in human, macaque, and mouse neocortex, revealing slower human PSD maturation and its potential link to neoteny.

The paper uses single-cell RNA-sequencing to identify dynamic molecular signatures during cortical arealization in the human brain, revealing gene expression patterns that define distinct cortical areas.

The paper identifies molecular subtypes of human interneuron progenitors and immature interneurons using single-cell RNA sequencing and compares them to mouse data, revealing species-specific gene programs.

Single-cell RNA sequencing of 289,000 first-trimester human brain cells identifies nine telencephalic progenitor subpopulations, a transient mesenchymal-like population, human-enriched C1orf61+ and ID4+ progenitors, and low early organoid fidelity.

This study maps the single-cell transcriptomic dynamics of hESC-RPE differentiation, identifies an intermediate progenitor, and shows in vivo maturation after transplantation.

In primary human cortical tissue and stem cell-derived organoids, SARS-CoV-2 infects astrocytes almost exclusively, apparently through DPP4 rather than ACE2, leaving them reactive and stressed.

This study characterizes 3D epigenomic landscapes during human corticogenesis, revealing chromatin looping and super interactive promoters involved in lineage-specific gene regulation.

This study shows that mTOR signaling regulates the morphology and migration of outer radial glia in the developing human cortex by affecting the actin cytoskeleton through CDC42.

The paper creates a chromatin accessibility atlas of the developing human telencephalon to identify regulatory elements and their role in gene expression and neurodevelopmental disorders.

The paper uses chimpanzee cerebral organoids to identify human-specific genes in cortical development and finds increased PI3K/AKT/mTOR activation in human outer radial glia.

This study examines the role of noncoding variation in autism spectrum disorder using whole genome sequencing of 2,076 genomes, finding no significant association after correction for multiple testing.

The paper investigates how miRNA-mRNA networks regulate cell-type-specific transcriptomes during human brain development using AGO2-HITS-CLIP, single-cell profiling, and bipartite network analysis.

The paper identifies human-specific NOTCH2NL genes linked to neurodevelopmental disorders and shows they affect cortical neurogenesis through Notch signaling.