Tanzila Mukhtar

A multimodal interrogation of Broca's area in the pediatric and adult human brain

The paper provides a high-resolution molecular and cellular analysis of Broca's area and motor cortex across developmental stages, identifying distinct cellular signatures and vulnerabilities to neurodevelopmental disorders.

Molecular dynamics of Brodmann Area 22 in development and autism

The paper identifies transcriptional and epigenomic differences in Brodmann Area 22 in autism, linking them to RFX3-dependent networks and verbal ability.

Single Cell Proteomics in the Developing Human Brain

This study develops a single-cell proteomics workflow to analyze the developing human brain, revealing transcriptome-proteome discordance and identifying molecular vulnerabilities in neurodevelopmental disorders.

Scalable high-fidelity human vascularized cortical assembloids recapitulate neurovascular co-development and cell specialization

This paper introduces vascularized cortical assembloids (vCAs) that model neurovascular co-development and show improved cellular specialization and connectivity compared to standard cortical organoids.

α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex

This study shows that α7 nicotinic acetylcholine receptors influence radial glia fate in human cortical development, with nicotine exposure altering neuronal differentiation and RG proliferation.

Fate plasticity of interneuron specification

This study shows that the identity of MGE-derived cortical interneurons can be dynamically influenced by their environment, with human 3D models promoting Pvalb expression over Sst.

Molecular and cellular dynamics of the developing human neocortex at single-cell resolution

This study maps the molecular and cellular dynamics of the developing human neocortex using single-nucleus data, revealing gene regulatory networks and a cancer-related progenitor subtype.

Safb1 regulates cell fate determination in adult neural stem cells by enhancing Drosha cleavage of NFIB mRNA

This study identifies Safb1 as a regulator of neuron production in adult hippocampal neural stem cells by enhancing Drosha-mediated cleavage of NFIB mRNA, preventing glial differentiation.

The protooncogene Ski regulates the neuron-glia switch during development of the mammalian cerebral cortex

The paper investigates the role of the protooncogene Ski in regulating the neuron-glia switch during mammalian cerebral cortex development and identifies its interaction with the BMP signaling pathway.

Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis

The paper maps transcriptional dynamics in murine cortical development, identifying lineage shifts and gene regulatory networks in neural stem cells, basal progenitors, and newborn neurons.

Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes

In primary human cortical tissue and stem cell-derived organoids, SARS-CoV-2 infects astrocytes almost exclusively, apparently through DPP4 rather than ACE2, leaving them reactive and stressed.

Universal Microfluidic System for Analysis and Control of Cell Dynamics

The paper introduces a microfluidic system for high-throughput cell culture and analysis, revealing signaling rules in neural stem cell differentiation.