RECON selects regions of interest from H&E images and reconstructs molecular profiles across entire slides at single-cell resolution for both transcriptomics and proteomics.

bioRxiv · Sep 1, 2026 · PreprintBioinformatics

α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex

Tanzila Mukhtar, Clara Siebert, Yuejun Jessie Wang, Mark-Phillip Pebworth, Matthew L. White, Tianzhi Wu, Tao Huang, Guolong Zuo, Jayden M. Ross, Jennifer Baltazar, Varun Upadhyay, Merut Shankar, Li Zhou, Isabel Lombardi-Coronel, Ishaan Mandala, , Arnold R. Kriegstein

This study shows that α7 nicotinic acetylcholine receptors influence radial glia fate in human cortical development, with nicotine exposure altering neuronal differentiation and RG proliferation.

Nature Communications · Jul 1, 2025Peer-reviewedNeuroscience

Fate plasticity of interneuron specification

Mohammed A. Mostajo-Radji, Walter Mancia, Arnar Breevoort, Jesus Gonzalez-Ferrer, Hunter E. Schweiger, Julian Lehrer, Li Zhou, Matthew T. Schmitz, Yonatan Perez, Tanzila Mukhtar, Ash Robbins, Julia S. F. Chu, Madeline G. Andrews, Frederika N. Sullivan, Darío Tejera, , Alex A. Pollen

This study shows that the identity of MGE-derived cortical interneurons can be dynamically influenced by their environment, with human 3D models promoting Pvalb expression over Sst.

iScience · Mar 27, 2025Peer-reviewedNeuroscience

A cross-species proteomic map reveals neoteny of human synapse development

Li Wang, Kaifang Pang, Li Zhou, Arantxa Cebrián‐Silla, Susana González-Granero, Shaohui Wang, Qiuli Bi, Matthew L. White, Brandon Ho, Jiani Li, Tao Li, Yonatan Perez, Eric Jinsheng Huang, Ethan A. Winkler, Mercedes F. Paredes, , Arnold R. Kriegstein

This study creates a cross-species proteomic map of synapse development in human, macaque, and mouse neocortex, revealing slower human PSD maturation and its potential link to neoteny.

Nature · Sep 13, 2023Peer-reviewedNeuroscience