Saccharomyces cerevisiae H2A copies differentially contribute to recombination and CAG/CTG repeat maintenance, with a role for H2A.1 threonine 126
Nealia C. M. House, Erica J. Polleys, Ishtiaque Quasem, Cailin E. Joyce, Oliver Takacsi-Nagy, Ryan B. Hayman, Jocelyn E. Krebs, Stephen M. Fuchs, Catherine H. Freudenreich
The paper investigates the role of H2A subtypes in CAG/CTG repeat instability in yeast, finding H2A.1 protects against expansion and its phosphorylation at Thr126 is critical for repair fidelity.
eLife · Dec 5, 2019Peer-reviewedGenetics