Catherine H. Freudenreich

The paper introduces GIDEON, an ILP framework to identify compensatory pathways in yeast genetic interaction networks, finding new BPM gene sets with potential antifungal drug target insights.

The paper shows that AT/TA repeats form DNA structures that are processed by nucleases and repositioned to the nuclear periphery for repair.

This study shows the DNA replication checkpoint facilitates relocation of collapsed CAG/CTG repeat forks to the nuclear periphery via kinetochore phosphorylation and microtubule recruitment in S. cerevisiae.

This paper shows C9orf72 expansions create a folate-sensitive fragile site FRA9A, leading to chromosomal instability and immune responses in patient cells and mice.

The paper shows that CAG/CTG repeats in ssDNA gaps influence repair kinetics, leading to repeat expansions or contractions and chromosome breaks.

This study shows that THO and TRAMP complexes prevent CAG repeat instability by reducing RNA polymerase stalling and transcription-replication conflicts in yeast.

The paper investigates the role of H2A subtypes in CAG/CTG repeat instability in yeast, finding H2A.1 protects against expansion and its phosphorylation at Thr126 is critical for repair fidelity.