Author

Issac Chang

Salk Institute for Biological Studies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Braden T. Stevenson· 1 shared Brent Y. ChickiD· 1 shared Deepshika RamananiD· 1 shared Diana C. HargreavesiD· 1 shared Emily C. DykhuizeniD· 1 shared Hannah Caroline Rattu MandiasiD· 1 shared Helen M. McRaeiD· 1 shared Joshua C. Bell· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Braden T. Stevenson

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1 paper

Recent·Most cited

Disruption of the ARID1A-containing SWI/SNF complex reprograms tumor-associated macrophages and enhances immunotherapy response

Helen M. McRae, Katherine M Nguyen, Queralt Vallmajó-Martín, Samuel A. Rivera, Braden T. Stevenson, K. Garrett Evensen, Mannix J. Burns, Joshua C. Bell, Hannah Caroline Rattu Mandias, Brent Y. Chick, Issac Chang, Emily C. Dykhuizen, Kelly Kersten, Susan M. Kaech, Deepshika Ramanan, Diana C. Hargreaves

This study shows that disrupting the ARID1A-containing SWI/SNF complex in tumor-associated macrophages enhances immunotherapy response by reprogramming their gene expression and improving checkpoint blockade efficacy.

bioRxiv · Sep 28, 2026 · PreprintCancer Biology