Author

Helen M. McRae

Salk Institute for Biological StudiesORCID 0000-0001-7396-0086Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Braden T. Stevenson· 1 shared Brent Y. ChickiD· 1 shared Deepshika RamananiD· 1 shared Diana C. HargreavesiD· 1 shared Emily C. DykhuizeniD· 1 shared Hannah Caroline Rattu MandiasiD· 1 shared Issac Chang· 1 shared Joshua C. Bell· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Braden T. Stevenson

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintSep 28, 2026

Disruption of the ARID1A-containing SWI/SNF complex reprograms tumor-associated macrophages and enhances immunotherapy response

Helen M. McRae, Katherine M Nguyen, Queralt Vallmajó-Martín…·Diana C. Hargreaves

This study shows that disrupting the ARID1A-containing SWI/SNF complex in tumor-associated macrophages enhances immunotherapy response by reprogramming their gene expression and improving checkpoint blockade efficacy.

DOI 10.64898/2026.09.25.754528

mousebulk RNA-seq

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