Emily C. Dykhuizen

This study identifies cBAF as a regulator of AR-V7 expression through chromatin-mediated transcriptional termination in CRPC.

This study shows that disrupting the ARID1A-containing SWI/SNF complex in tumor-associated macrophages enhances immunotherapy response by reprogramming their gene expression and improving checkpoint blockade efficacy.

This study shows that PBRM1 in PBAF is essential for EMT and metastasis in breast cancer by enabling promoter targeting and DNA accessibility for TGFβ1-inducible genes.

This study shows that PBRM1 and VHL cooperate to enhance ferroptosis resistance in ccRCC by modulating lipid and iron metabolism.

This study shows that Bicra/Gltscr1 knockout mice die perinatally due to defective fetal liver macrophages that impair erythrocyte maturation.

This study shows the nBAF complex facilitates activity-induced transcription of IEGs by regulating RNA Polymerase II elongation through its assembly and ATPase activity.