Cancer BiologybioRxivPreprint
Disruption of the ARID1A-containing SWI/SNF complex reprograms tumor-associated macrophages and enhances immunotherapy response
Helen M. McRae, Katherine M Nguyen, Queralt Vallmajó-Martín…·Diana C. Hargreaves
This study shows that disrupting the ARID1A-containing SWI/SNF complex in tumor-associated macrophages enhances immunotherapy response by reprogramming their gene expression and improving checkpoint blockade efficacy.
DOI 10.64898/2026.09.25.754528