Mannix J. Burns

This study shows that disrupting the ARID1A-containing SWI/SNF complex in tumor-associated macrophages enhances immunotherapy response by reprogramming their gene expression and improving checkpoint blockade efficacy.

CellScope improves cell atlas construction by integrating UMAP with hierarchical clustering, enhancing clustering performance, visualization, and interpretability across single-cell datasets.

The paper identifies cell type specific driver genes in autism-associated copy number loci using cerebral organoids and validates findings with CRISPR/Cas9-edited mosaic organoids.