Aging disrupts transcriptional programs for memory updating in the dorsal hippocampus and reveals a required role for Tent5a in reconsolidation
Chad A. Brunswick, Annie G. Defina, Trinity A. Wood, Aswathy Sebastian, Alexandria R. McKenna, Shoko Murakami, Pu-Hsun Chiu, Shannon M. Jordan, Gretchen C. Pifer, Istvan Albert, Janine L. Kwapis
The paper identifies Tent5a as a regulator of reconsolidation-mediated memory updating in the dorsal hippocampus and shows aging disrupts transcriptional programs involved in this process.
bioRxiv · Sep 14, 2026 · PreprintNeuroscience