Chad A. Brunswick

Aging disrupts transcriptional programs for memory updating in the dorsal hippocampus and reveals a required role for Tent5a in reconsolidation

The paper identifies Tent5a as a regulator of reconsolidation-mediated memory updating in the dorsal hippocampus and shows aging disrupts transcriptional programs involved in this process.

Old mice fail to integrate a memory update into an existing hippocampal engram.

This study shows that old mice have difficulty updating existing memories in the hippocampus, but re-engaging the original memory engram can improve this ability.

Pharmacological HDAC3 inhibition alters memory updating in young and old mice

This study shows that HDAC3 inhibition improves memory updating in old mice but impairs it in young mice, suggesting HDAC3 regulates memory update strength and expression balance.