Aswathy Sebastian

The paper identifies Tent5a as a regulator of reconsolidation-mediated memory updating in the dorsal hippocampus and shows aging disrupts transcriptional programs involved in this process.

This study identifies Def1 as a cytoplasmic regulator of mRNA translation and decay by linking ribosome status to mRNA degradation through ubiquitylation.

The paper shows that the human CCR4-NOT complex suppresses pervasive transcription and retrotransposable elements by repressing transcription and stabilizing their RNAs.

The paper tests chromatin condensation inhibitors in a retinal degeneration mouse model, showing they preserve retinas through different mechanisms.

This study identifies the global release of translational repression in Plasmodium parasites during host-to-vector transmission using transcriptomics and proteomics.

The paper tests over 2,600 natural twister ribozymes using CHiTA, finding 94% are active and showing structural tolerance.

The paper shows that CCR4-NOT regulates gene expression and suppresses retrotransposon activation by modulating RNA decay and KZNF gene expression.

This study identifies Per1 as a circadian gene that modulates memory consolidation in the dorsal hippocampus, showing diurnal effects on long-term memory performance in mice.