Janine L. Kwapis

Aging disrupts transcriptional programs for memory updating in the dorsal hippocampus and reveals a required role for Tent5a in reconsolidation

The paper identifies Tent5a as a regulator of reconsolidation-mediated memory updating in the dorsal hippocampus and shows aging disrupts transcriptional programs involved in this process.

Old mice fail to integrate a memory update into an existing hippocampal engram.

This study shows that old mice have difficulty updating existing memories in the hippocampus, but re-engaging the original memory engram can improve this ability.

Age and Sex Influence Diurnal Memory Oscillations, Circadian Rhythmicity, and Per1 Expression

This study investigates how sex and age affect diurnal memory oscillations, circadian rhythms, and Per1 expression in mice, finding sex has a greater impact than age on circadian patterns and memory performance.

Alcohol consumption drives sex- and region- specific disruption of somatostatin signaling in mice

This study shows alcohol consumption disrupts somatostatin signaling in the prelimbic prefrontal cortex of mice, with potential implications for alcohol use disorder treatment.

Pharmacological HDAC3 inhibition alters memory updating in young and old mice

This study shows that HDAC3 inhibition improves memory updating in old mice but impairs it in young mice, suggesting HDAC3 regulates memory update strength and expression balance.

The clock gene Per1 expression may exert diurnal control over hippocampal memory consolidation

This study identifies Per1 as a circadian gene that modulates memory consolidation in the dorsal hippocampus, showing diurnal effects on long-term memory performance in mice.

PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure

The paper identifies PP4-dependent HDAC3 dephosphorylation as a mechanism distinguishing axonal regeneration from regenerative failure in nerve injuries.

Epigenetic regulation of the circadian gene Per1 in the hippocampus mediates age-related changes in memory and synaptic plasticity

This study shows that HDAC3 restricts long-term memory and synaptic plasticity in aging hippocampus by repressing Per1, a circadian gene, without affecting circadian rhythms.