4'-fluorouridine is a potent inhibitor of Oropouche virus in vitro and in animal infection models
Martin Ferrié, Maïlis Darmuzey, Itona Tarillon, Thibault Tubiana, Mona Khan, Tania Roskams, Birgit Weynand, Dietmar Rudolf Thal, Niels Cremers, Stijn Hendrickx, Kim Donckers, Thayara Morais Portal, Bert Vanmechelen, Viktor Lemmens, Joana Rocha‐Pereira, , Johan H. Neyts
This study shows 4'-fluorouridine inhibits Oropouche virus replication in vitro and in animal models, with no resistant variants observed.
bioRxiv · Sep 22, 2025 · PreprintMicrobiology