Thibault Tubiana

A novel dimerization site in non-structural protein 5A of hepatitis C virus regulates viral replication fitness

This study identifies a dimerization site in NS5A that enhances HCV replication fitness by promoting self-interaction, which inhibits NS3 and NS5B activity.

ZDHHC17-Mediated Palmitoylation of Hepatitis E Virus ORF3 Protein Regulates Vectorial Trafficking in Polarized Epithelial Cells

This study identifies ZDHHC17-mediated palmitoylation of HEV ORF3 protein as critical for directional secretion in polarized epithelial cells.

Functional study of two flexible regions of the hepatitis E virus ORF1 replicase

This study investigates two flexible regions of the HEV ORF1 replicase using structural modeling and mutagenesis, showing their functional importance in viral replication.

4'-fluorouridine is a potent inhibitor of Oropouche virus in vitro and in animal infection models

This study shows 4'-fluorouridine inhibits Oropouche virus replication in vitro and in animal models, with no resistant variants observed.

The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistence in hepatocytes

This study identifies ORF2 as a key HEV protein that suppresses antiviral responses in hepatocytes, enabling viral persistence.

Studying self-assembly of norovirus capsid by a combination of in silico methods

The paper uses in silico methods to study the self-assembly of norovirus capsid proteins and revises a previous assembly model.

Dissecting peripheral protein-membrane interfaces

The paper analyzes amino acid composition and structural patterns in peripheral membrane protein interfaces using experimental and AlphaFold models to identify key residues and functional motifs.