Aggregation of HAPLN2, a component of the perinodal extracellular matrix, is a hallmark of physiological brain aging in mice
Ayaka Watanabe, Shoshiro Hirayama, Itsuki Kominato, Sybille Marchese, Pietro Esposito, Vanya Metodieva, Taeko Kimura, Hiroshi Kameda, Terunori Sano, Masaki Takao, Sho Takatori, Masato Koike, Juan Alberto Varela, Taisuke Tomita, Shigeo Murata
This study identifies HAPLN2 aggregation as a feature of brain aging in mice, linking it to microglial activation and potential brain inflammation.
bioRxiv · Jan 9, 2025 · PreprintBiochemistry