ImmunologybioRxivPreprint
A chromatin relay from AIRE to ETS transcription factors sustains peripheral antigen expression in the thymic mimetic cells to ensure central tolerance.
Kenta Horie, Takahisa Miyao, Yuko Yamagata…·Taishin Akiyama
The paper identifies EHF and ELF3 as key ETS transcription factors that sustain AIRE-primed gene expression in post-AIRE mimetic thymic epithelial cells, ensuring central tolerance.