Recognition and catalytic mechanism of tRNA m3C methyltransferase METTL6
Jana Aupič, Iven Hollmer, Laura Tengo, Peter A. Sehr, Eva Kowalinski, Alessandra Magistrato
This study defines the mechanism by which METTL6 and SerRS cooperatively recognize and catalyze tRNA m3C methylation using simulations and in vitro experiments.
bioRxiv · Jun 25, 2025 · PreprintBiochemistry