Laura Tengo

The RNA helicase KREH2 directly binds the RESC1-RESC2 complex in trypanosomatid mitochondrial RNA editing

This study identifies a direct interaction between the RNA helicase KREH2 and the RESC1-RESC2 complex in trypanosomatid mitochondrial RNA editing using biochemical and structural methods.

The C-terminus of the KREH1 helicase is important for RNA binding and association with mitochondrial RNA editing complexes in T. brucei

This study investigates the role of KREH1's C-terminus in RNA binding and its interaction with mitochondrial RNA editing complexes in T. brucei.

Recognition and catalytic mechanism of tRNA m3C methyltransferase METTL6

This study defines the mechanism by which METTL6 and SerRS cooperatively recognize and catalyze tRNA m3C methylation using simulations and in vitro experiments.

Structural basis of tRNA recognition by the m3C-RNA-methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase

The paper reports the cryo-EM structure of METTL6 in complex with SerRS and tRNASer, revealing their interaction and methylation mechanism.

Structural basis of Spliced Leader RNA recognition by the Trypanosoma brucei cap-binding complex

This paper reports cryo-EM structures of the Trypanosoma brucei cap-binding complex (TbCBC) and identifies its interactions with the spliced leader RNA.

Sequence-independent substrate selection by the eukaryotic wobble base deaminase ADAT2/3 involves multiple protein domains and distortion of the tRNA anticodon loop

This study presents the first structure of a eukaryotic ADAT2/3 deaminase bound to tRNA, revealing sequence-independent substrate selection and a novel gating mechanism for substrate entry.