Author

Iz Varghese

Brown University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Assay:protein structure· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Brenda M. RubensteiniD· 2 shared George P. LisiiD· 2 shared Ananya ShuklaiD· 1 shared Anna S Bock· 1 shared Divya RajendraniD· 1 shared Flavia Maria Galeazzi· 1 shared Fuming ZhangiD· 1 shared Gabriel Monteiro da SilvaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

Brenda M. RubensteinORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Exploring the GM-CSF Histidine Triad as a Modulator of Structure, Molecular Motion, and Ligand Binding

Jennifer Y. Cui, Iz Varghese, Anna S Bock, Mariana Floody, Fuming Zhang, Brenda M. Rubenstein, George P. Lisi

This study investigates how histidine residues in GM-CSF affect its structure, flexibility, and ligand binding at physiological pH.

RSC Chemical Biology · Jan 1, 2026Peer-reviewedBiophysics

Allosteric Modulation of MIF-2 Structure, Catalysis, and Biological Signaling via Cysteine Residues and a Small Molecule, Ebselen

Vinnie Widjaja, Sirena M. D’Orazio, Pragnya Das, Xander Takada, Divya Rajendran, Yuanjun Shi, Iz Varghese, Yannie Lam, Jimin Wang, Víctor S. Batista, Vineet Bhandari, George P. Lisi

This study investigates how Ebselen modulates MIF-2 structure, catalysis, and signaling through cysteine residues, revealing its impact on trimer stability and function.

bioRxiv · May 15, 2025 · PreprintBiophysics

FastConformation: A Standalone ML-Based Toolkit for Modeling and Analyzing Protein Conformational Ensembles at Scale

Flavia Maria Galeazzi, Gabriel Monteiro da Silva, Pablo Ricardo Arantes, Iz Varghese, Ananya Shukla, Brenda M. Rubenstein

FastConformation provides a user-friendly tool for generating and analyzing protein conformational ensembles using AlphaFold 2, enabling faster and more accessible conformational predictions than traditional methods.

bioRxiv · May 9, 2025 · PreprintBiophysics