Interferon-independent STING enforces epithelial genome-integrity checkpoint to restrain tumor evolution
Xiang Hang, Martina Macino, Clemens Woitaske-Proske, Nicholas Bodenstein, J P Bernardes, Florian Tran, Nicole A Schmid, Gabriela Rios Martini, Felix Wottawa, J Bornhaeuser, Nassim Kakavand, Oliver Dyck Dionisi, Silke van den Bossche, Guang Yang, Qicong Wu, , Konrad Aden
This study shows that STING acts as a genome-integrity checkpoint in epithelial cells, independent of interferon, and its loss leads to chromosomal instability and tumor development.
bioRxiv · Mar 25, 2026 · PreprintCancer Biology