Björn Konukiewitz

Organoids serve as viable in vitro model for functional precision medicine for mesonephric-like adenocarcinoma of the ovary

The paper demonstrates that ovarian cancer organoids derived from mesonephric-like adenocarcinoma can be used for functional precision medicine, showing sensitivity to binimetinib and resistance to standard chemotherapeutics.

Interferon-independent STING enforces epithelial genome-integrity checkpoint to restrain tumor evolution

This study shows that STING acts as a genome-integrity checkpoint in epithelial cells, independent of interferon, and its loss leads to chromosomal instability and tumor development.

Latent plasticity of the human pancreas across development, health, and disease.

The paper constructs a single-cell multiomics atlas of the human pancreas across development, health, and T2D, identifying plastic cell states and lineage trajectories.