Hepatitis C virus replication fitness as a determinant of antiviral therapy outcome
Ha-Gyu Thomas Seong, Tomke Arand, Colin Forster, Micha Böhm, Eva Heger, John McLauchlan, Christoph Sarrazin, J Dietz, Rolf Kaiser, Volker Lohmann, Paul Rothhaar
This study examines how HCV replication fitness affects antiviral treatment outcomes, finding that high replication fitness can compensate for resistance mutations and contribute to DAA treatment failure.
bioRxiv · Feb 4, 2026 · PreprintMicrobiology