A novel dimerization site in non-structural protein 5A of hepatitis C virus regulates viral replication fitness
Paul Rothhaar, Thibault Tubiana, Colin Forster, Gabriel Vanegas Arias, Tomke Arand, Noemi Schäfer, Philipp Ralfs, Christian Heuss, Antonio Piras, Andreas Pichlmair, Xavier Hanoulle, Stéphane Bressanelli, Volker Lohmann
This study identifies a dimerization site in NS5A that enhances HCV replication fitness by promoting self-interaction, which inhibits NS3 and NS5B activity.
PLoS Pathogens · Aug 5, 2026Peer-reviewedMicrobiology