Single-cell transcriptional changes of artemisinin-sensitive K13C580 and artemisinin-resistant K13580Y Plasmodium falciparum upon dihydroartemisinin exposure
S. V. Connelly, C. Cunningham, I. Petrow, N. Rustamzade, J. Zuromski, D. M. Sipolski, C. P. Nixon, J. D. Kurtis, J. J. Juliano, J. A. Bailey, C. I. Oduor
This study uses single-cell RNA sequencing to compare transcriptional changes in artemisinin-sensitive and resistant Plasmodium falciparum strains after dihydroartemisinin exposure, identifying metabolic and protein export differences and a potential therapeutic target.
bioRxiv · Dec 6, 2023 · PreprintMicrobiology