M. A. Luftig

Epstein-Barr virus protein EBNA-LP engages YY1 through leucine-rich motifs to promote naïve B cell transformation

This study identifies EBNA-LP's role in promoting naive B cell transformation by interacting with YY1 through conserved leucine-rich motifs.

Fate-resolved gene regulatory signatures of individual B lymphocytes in the early stages of Epstein-Barr Virus infection

This paper uses single-cell transcriptomics and chromatin accessibility to model early EBV infection dynamics and identifies regulatory signatures in B lymphocytes.

Comparing instance segmentation methods for analyzing clonal growth of single cells in microfluidic chips

The paper compares segmentation methods for analyzing clonal growth in microfluidic chips, finding unsupervised learning methods more accurate and flexible than supervised approaches.

Massively parallel quantification of phenotypic heterogeneity in single cell drug responses

The paper develops a single-cell phenotyping tool to measure clonal properties at scale, applying it to study drug responses in AML clones and identifying rare resistance phenotypes.

Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas

This study shows that inhibiting MCT1 and MCT4 in EBV-driven lymphomas disrupts metabolism, leading to growth arrest and sensitization to metformin, revealing a potential therapeutic strategy.

Epstein-Barr virus promotes survival through germinal center light zone chromatin architecture

The paper shows EBV promotes survival by mimicking germinal center light zone chromatin architecture to regulate BFL-1 expression in lymphoblastoid cell lines.

Single-cell characterization of transcriptomic heterogeneity in lymphoblastoid cell lines

This study uses single-cell RNA sequencing to analyze transcriptomic heterogeneity in lymphoblastoid cell lines and shows how stochastic factors influence clonal evolution.

Identification of Host Biomarkers of EBV Latency IIb and Latency III

This study identifies mRNA biomarkers distinguishing EBV latency IIb and III states using transcriptomic analysis of EBV-infected B cells.

The Epstein-Barr Virus miR-BHRF1 microRNAs Regulate Viral Gene Expression in cis

This paper shows that EBV miR-BHRF1 microRNAs regulate EBNA-LP mRNA stability in cis, not trans, and their loss reduces B-cell transformation.

Intracellular BH3 profiling reveals shifts in anti-apoptotic dependency in B-cell maturation and activation

The paper uses intracellular BH3 profiling to analyze B-cell subsets and their anti-apoptotic dependencies during maturation and activation, revealing distinct dependencies in different stages.