J. Y. Zhou

Platelet-Localized ST6Gal1 Does Not Impact IgG Sialylation

This study investigates whether platelet-localized ST6Gal1 affects IgG sialylation and finds no significant impact.

Plasma ST6Gal1 is Dispensable for IgG Sialylation

The paper shows that plasma ST6Gal1 is not required for IgG 2,6-sialylation, as IgG sialylation remains normal in mice lacking ST6Gal1 in hepatocytes or B cells.

Divergent Golgi Trafficking Limits B cell-Mediated IgG Sialylation

This study shows that IgG sialylation and fucosylation diverge from B cell surface glycoprotein modification, with IgG avoiding sialylation and favoring fucosylation due to distinct trafficking patterns.

Single-cell characterization of transcriptomic heterogeneity in lymphoblastoid cell lines

This study uses single-cell RNA sequencing to analyze transcriptomic heterogeneity in lymphoblastoid cell lines and shows how stochastic factors influence clonal evolution.

Integration of IL-2 and IL-4 Signals Coordinates Divergent Regulatory T cell Responses and Drives Therapeutic Efficacy

This study shows that regulatory T cells integrate IL-2 and IL-4 signals to produce a response distinct from individual cytokine effects, enhancing IL-10 production and therapeutic outcomes in mouse models of asthma and multiple sclerosis.